Thymogen (L-Glu-L-Trp)
Thymogen is a peptide made of just two amino acids, isolated from the thymus gland as its smallest immunologically active fragment. It is studied as a gentle agent for restoring immunity, for example in older adults after surgery.
2 amino acids: L-glutamic acid + L-tryptophan. Glu-Trp. ~333 Da. A dipeptide isolated from the thymus. The smallest immunologically active fragment.
One of Khavinson's most "pure" immune bioregulators. RCT in older cancer patients (double-blind): restoration of immunity after surgery, ↓postoperative complications. Reduced carcinogenesis in rats 1.5-fold. A gentle and safe immunostimulant.
Stimulates T-cell differentiation and maturation. ↑synthesis of IL-2 and IFN-γ. Regulates cytokine balance. ↓inflammatory cascades. ↑DNA synthesis in thymic cells. Gentle activation without overstimulation.
Studies used 100 mcg (0.1 mg) IM once daily for a course of 10 days; the solution was prepared with 1 ml of bacteriostatic water. The intranasal form (Thymogen 0.01%) was used at 1–2 doses in each nostril 2–3 times/day for a course of 5–10 days.
Level A-C Human clinical trials. There are randomized controlled trials (RCTs), or the compound has been approved by a regulatory agency. The most reliable level. Human RCTs (oncology, older adults). Well studied in Russian science.
⚠️ Most studies are Russian, with small samples. Two routes of administration (IM and intranasal). Research only.
Research peptides are laboratory reagents (Research Use Only). They are not medicines and are not intended for use in humans or animals.