Thymalin

In simple words

Thymalin is a mixture of short peptides from the thymus gland of cattle. In the context of recovery, it is studied as a support for immunity during wound healing and after surgery.

What this molecule is

A polypeptide complex from bovine thymus. Short peptide fragments of the thymus. (Detailed profile — Ch. 3 and Ch. 8)

Why it is studied

In the context of regeneration: supports immune surveillance during wound healing. ↑NK cells (infection control in the injury area). ↓Inflammation in chronic wounds. Speeds recovery after surgical procedures.

How it works

↑T lymphocytes in the injury area → ↑immune surveillance. ↓Pro-inflammatory cytokines in chronic wound inflammation. ↑Antioxidant protection of regenerating tissue.

Doses used in studies

Studies used 5-10 mg IM once/day × 5-10 days alongside a regenerative protocol.

Combined with in studies

• BPC-157 — regeneration + immune surveillance
• GHK-Cu — tissue
• LL-37 — antimicrobial

Level of evidence

Level B Human observational data. There are studies in humans, but they are small, uncontrolled, or cohort studies. The data are encouraging but need confirmation. cohort data from Khavinson.

Important to know

⚠️ Supporting role in regeneration. Main profile — Ch. 3 and Ch. 8.

Studies in PubMed

1. Peptides of pineal gland and thymus prolong human life. (Neuro Endocrinol Lett, 2003)
2. Results and Prospects of Using Activator of Hematopoietic Stem Cell Differentiation in Complex Therapy for Patients with COVID-19. (Stem Cell Rev Rep, 2021)
3. Thymalin: Activation of Differentiation of Human Hematopoietic Stem Cells. (Bull Exp Biol Med, 2020)
4. The Influence of KE and EW Dipeptides in the Composition of the Thymalin Drug on Gene Expression and Protein Synthesis Involved in the Pathogenesis of COVID-19. (Int J Mol Sci, 2023)