Pinealon

In simple words

Pinealon is a very short peptide of three amino acids, a brain bioregulator from Khavinson's school. It is studied as a way to support nerve cells in age-related memory decline, sleep disorders, and after head injuries.

What this molecule is

Glu-Asp-Arg — 3 aa, a tripeptide. An analog of Cerluten (AEDR) from Khavinson's bioregulators. A peptide bioregulator of the brain. ~417 Da.

Why it is studied

A neuroprotective brain bioregulator from Khavinson (Institute of Bioregulation and Gerontology). Used to improve cognitive function in age-related changes and sleep disorders, and for recovery after TBI. ↑neuron viability, ↓free radicals.

How it works

The EDR tripeptide interacts with promoter regions of neuronal DNA → ↑expression of neuroprotective genes (BDNF, NGF, SOD). ↑PCNA (proliferation of neuronal progenitors). ↓oxidative stress in the CNS. Possible regulation via melatonin pathways (link to the pineal gland).

Doses used in studies

Studies used 10 mg IM once a day for a 10-day course; repeat courses 2-3 times/year. An alternative option was 5-10 mg SC.

Combined with in studies

• Epitalon — pineal synergy: both regulate the neuroendocrine axis
• DSIP — sleep + neuroprotection
• Semax — BDNF from different angles

Level of evidence

Level C-D Animal studies. Effects have been shown in animals. Whether they carry over to humans has not been proven. Preclinical data and Khavinson's reviews. No clinical data.

Important to know

⚠️ No direct RCTs. The evidence base comes from Khavinson's Russian laboratory. Research only.

Studies in PubMed

1. Pinealon increases cell viability by suppression of free radical levels and activating proliferative processes. (Rejuvenation Res, 2011)
2. Neuroprotective Effects of Tripeptides-Epigenetic Regulators in Mouse Model of Alzheimer's Disease. (Pharmaceuticals (Basel), 2021)
3. Short Peptides Protect Fibroblast-Derived Induced Neurons from Age-Related Changes. (Int J Mol Sci, 2024)
4. Short peptides stimulate serotonin expression in cells of brain cortex. (Bull Exp Biol Med, 2014)
5. Neuroepigenetic Mechanisms of Action of Ultrashort Peptides in Alzheimer's Disease. (Int J Mol Sci, 2022)
6. [EFFECT OF SYNTHETIC PEPTIDES ON AGING OF PATIENTS WITH CHRONIC POLYMORBIDITY AND ORGANIC BRAIN SYNDROME OF THE CENTRAL NERVOUS SYSTEM IN REMISSION]. (Adv Gerontol, 2015)