Pinealon

In simple words

Pinealon is a peptide of three amino acids developed in St. Petersburg to support the brain. It is studied as a protector of nerve cells in memory and sleep problems and during recovery from head injuries.

What this molecule is

Glu-Asp-Arg — 3 aa, a brain neuropeptide. Analog of Cerluten (AEDR). IBG RAS. ~417 Da.

Why it is studied

Neuroprotective brain bioregulator. ↑Neuronal viability, ↓free radicals. Used in cognitive impairment, sleep disorders, and recovery after TBI. Linked to regulation of the pineal gland.

How it works

Epigenetic activation of neurons → ↑BDNF, ↑NGF, ↑SOD. ↑PCNA (neuronal progenitors). Possible regulation via melatonin pathways.

Doses used in studies

Studies used 10 mg IM once a day for 10 days; 2–3 courses a year.

Combined with in studies

• Epitalon — pineal synergy
• DSIP — sleep
• Semax — BDNF

Level of evidence

Level C-D Animal studies. Effects have been shown in animals. Whether they carry over to humans has not been proven.

Important to know

Russian data only. Research only.

Studies in PubMed

1. Pinealon increases cell viability by suppression of free radical levels and activating proliferative processes. (Rejuvenation Res, 2011)
2. Neuroprotective Effects of Tripeptides-Epigenetic Regulators in Mouse Model of Alzheimer's Disease. (Pharmaceuticals (Basel), 2021)
3. Short Peptides Protect Fibroblast-Derived Induced Neurons from Age-Related Changes. (Int J Mol Sci, 2024)
4. Short peptides stimulate serotonin expression in cells of brain cortex. (Bull Exp Biol Med, 2014)
5. [EFFECT OF SYNTHETIC PEPTIDES ON AGING OF PATIENTS WITH CHRONIC POLYMORBIDITY AND ORGANIC BRAIN SYNDROME OF THE CENTRAL NERVOUS SYSTEM IN REMISSION]. (Adv Gerontol, 2015)