AOD-9604

In simple words

AOD-9604 is a piece of the growth hormone molecule that was studied as a fat-burning agent with no effect on growth. A large human study showed no notable advantage over placebo.

What this molecule is

YLRIVQCRSVEGSCGF — 16 aa, hGH fragment, positions 176-191. ~1817 Da.

Why it is studied

Lipolytic GH fragment without growth effects. One human study (oral). Phase 2b failed in 2007 (536 people) — no significant superiority over placebo was shown. Used as an add-on to GLP-1.

How it works

↑β3-adrenergic receptors → ↑HSL → ↑lipolysis. ↓Acetyl-CoA carboxylase → ↓lipogenesis. Does not affect GH receptors, IGF-1, or glucose.

Doses used in studies

In practice, 250–300 mcg SC was used in the morning on an empty stomach for 8–12 weeks (practice, not validated).

Combined with in studies

• CJC-1295/Mod-GRF — different mechanisms
• L-Carnitine
• GLP-1 agonists — additional lipolysis

Level of evidence

Level B-C Human observational data. There are studies in humans, but they are small, uncontrolled, or cohort studies. The data are encouraging but need confirmation.

Important to know

🔴 Phase 2b failed (536 people, 2007). WADA ban S0 (2022). Almost no clinical data. Research only.

Studies in PubMed

1. AOD-9604 Metabolic. (Curr Opin Investig Drugs, 2004)
2. The effects of human GH and its lipolytic fragment (AOD9604) on lipid metabolism following chronic treatment in obese mice and beta(3)-AR knock-out mice. (Endocrinology, 2001)
3. Increase of fat oxidation and weight loss in obese mice caused by chronic treatment with human growth hormone or a modified C-terminal fragment. (Int J Obes Relat Metab Disord, 2001)
4. Effects of oral administration of a synthetic fragment of human growth hormone on lipid metabolism. (Am J Physiol Endocrinol Metab, 2000)
5. Effect of Intra-articular Injection of AOD9604 with or without Hyaluronic Acid in Rabbit Osteoarthritis Model. (Ann Clin Lab Sci, 2015)
6. Detection and in vitro metabolism of AOD9604. (Drug Test Anal, 2015)