Adamax

In simple words

Adamax is a modified version of Semax with protected molecule ends, marketed as a “boosted Semax.” There are no scientific publications on it; all data are taken from regular Semax.

What this molecule is

Ac-Met-Glu-His-Phe-Arg-Trp-Gly-Pro-Gly-Pro-NH₂ — 10 aa. Semax with N-acetylation and C-amidation. ~1235 Da.

Why it is studied

Positioned as a “boosted Semax” with increased resistance to exopeptidases at both ends. The presumed advantages vs Semax have not been confirmed by comparative studies. Popular in nootropic communities.

How it works

Presumably identical to Semax: ↑BDNF/TrkB, ↑dopamine/serotonin. Acetylation changes Cu²⁺/Zn²⁺ coordination (PMID: 27586814) — theoretically ↑antioxidant potential.

Doses used in studies

No clinical data. By extrapolation from Semax, 100-300 mcg intranasally 1-2 times/day have been described.

Combined with in studies

• Selank
• Noopept
• Semax — the same molecule, not at the same time

Level of evidence

Level C-D Animal studies. Effects have been shown in animals. Whether they carry over to humans has not been proven. ⚠️ PubMed has no PMIDs under “Adamax.” All data are for Semax.

Important to know

🔴 “Adamax” is a commercial name used by suppliers. Zero publications in PubMed. The presumed advantages vs Semax have not been proven by a single comparative study. The studied nootropic is Semax (registered in Russia, dozens of PMIDs). Research only.

Studies in PubMed

1. Influence of the N-terminus acetylation of Semax, a synthetic analog of ACTH(4-10), on copper(II) and zinc(II) coordination and biological properties. (J Inorg Biochem, 2016)
2. Semax, an analog of ACTH(4-10) with cognitive effects, regulates BDNF and trkB expression in the rat hippocampus. (Brain Res, 2006)
3. Neuroprotective and antiamnesic effects of Semax during experimental ischemic infarction of the cerebral cortex. (Bull Exp Biol Med, 2006)
4. [Effectiveness of semax in acute period of hemispheric ischemic stroke (a clinical and electrophysiological study)]. (Zh Nevrol Psikhiatr Im S S Korsakova, 1997)
5. Semax, an analogue of adrenocorticotropin (4-10), is a potential agent for the treatment of attention-deficit hyperactivity disorder and Rett syndrome. (Med Hypotheses, 2007)
6. [The efficacy of semax in the tretament of patients at different stages of ischemic stroke]. (Zh Nevrol Psikhiatr Im S S Korsakova, 2018)